A mutant version of hemoglobin lacks the ion pairs at the interface between the a and 5 subunits. Explain what effect the lack of these ion pairs has on 02 transport.

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Hemoglobin

Hemoglobin utilizes quaternary structure to transport oxygen efficiently.

a.  A mutant version of hemoglobin lacks the ion pairs at the interface between the a and 5 subunits. Explain what effect the lack of these ion pairs has on 02 transport.

  • As part of your explanation  include your hypothesized effect on Heme M’s p02 and its ability to perform its normal function. 6-8 Sentences

b. Do you predict Heme M to be a lethal mutation? Why or why not? (2-3 sentences)