Systems genetics identifies :Explain how the authors use their data to link Hp1bp3 to memory capacity in humans? Explain how the authors use their data to make the connection between Hp1bp3 and Alzheimer’s disease?

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Systems genetics identifies

Answer questions 1-5 by reading the following article. All answers should come from SOLELY from the following journal article . The answers should be 1-2 sentence and it should summarize the answers EFFECTIVELY and CONCISELY in 1-2 sentences.

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M., Garfinkel, B. P., Wilmott, L. A., Ignatowska-Jankowska, B. M., Citri, A., Orly, J., Lu, L., Overall, R. W., Mulligan, M. K., Kempermann, G., Williams, R. W., O’Connell, K. M., & Kaczorowski, C. C. (2016). Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging. Neurobiology of aging, 46, 58–67. https://doi.org/10.1016/j.neurobiolaging.2016.06.008

  1. The authors refer to CFM testing, what does this acronym stand for and describe what it helps the authors test in this study?
  2.  Explain how the authors use their data to make the connection between Hp1bp3 and Alzheimer’s disease?
  3. Explain how the authors use their data to link Hp1bp3 to memory capacity in humans?
  4.  Why did the authors use the BXD mice in this study?
  5. How did the authors use functional validation to confirm their hypothesized link between Hp1bp3 and cognitive function.